In order to reduce the self-weight of precast concrete pavement slab, the concrete hollow slab was studied by using ABAQUS, the optimal length, width and thickness and circular hollow type of precast concrete solid slab were recommended. The local sizes of the circular section were optimized, and the influences of the radius, numbers and height of circle on the maximum flexural-stress, the maximum vertical displacement, the maximum compressive stress and shear stress of the slab were analyzed. Entropy weight method and technique for order preference by similarity to an ideal solution method were introduced to optimize multiple parameters, and the optimal hollow combination was obtained as 10 circles with a radius of 60 mm and a center height of 160 mm. By comparing the mechanical performance of hollow slab with solid slab, it was found that the difference was marginal, while optimized hollow slab could lead to a 970 kg self-weight reduction. The precast concrete hollow slab, the circular hollow type and its local size were proposed and recommended.