Engineering geological and hydro-geological conditions are highly changing and complex in karst developing district of tunnels. Water inrush, mad (sand) flush, collapse and some other geological hazards often occur in the construction of karst tunnels, which often bring about great casualties, economic losses and environmental destruction of karst hydrogeology. According to the applicable scope, merits and drawbacks of different geological prediction methods, an integrated advanced geological prediction methods wasput forth to predict water inrush, mad flush, fault fracture zones, karst classification and stability analysis of rock mass. A multi-step warning and prediction system was established, which included macroscopic, long-term, short-term geological prediction methods and geological precursory prediction methods. The multi-step warning and prediction system was successfully applied in the construction of the Qiyueshan Tunnel and others.