JOURNAL OF SHANDONG UNIVERSITY (ENGINEERING SCIENCE) ›› 2016, Vol. 46 ›› Issue (3): 106-111.doi: 10.6040/j.issn.1672-3961.0.2015.395

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Investigation of the release behavior of methylene blue from silica@octacalcium phosphate as drug carrier

LI Chengfeng, LIU Qun, WANG Wenhao, WANG Baiwei, YANG Zanzhong   

  1. School of Materials Science and Engineering, Shandong University of Technology, Zibo 255049, Shandong, China
  • Received:2015-12-02 Online:2016-06-30 Published:2015-12-02

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Abstract: A modified Pechinni method was employed to synthesize the drug carrier of silica-MB@OCP, which was achieved through deposition of octacalcium phosphate(OCP)on MB-loaded silica particle(silica-MB). The influences of reaction conditions on structural evolution of drug carrier, modulation of release behaviors and decomposition of drug vehicle were studied. The phase, chemical constitution and morphology of silica-MB@OCP were significantly influenced by the molecular weight of polyethylene glycol(PEG), adding amount of PEG and citric acid. The variations of the cumulative release and the ratio of monomer versus dimers of MB with time were sensitivity with the structure of silica-MB@OCP and the pH value of culture solution, which influenced the diffusion of MB. In comparison with those of silica-MB, the degradation ratios of silica-MB in phosphate buffered saline and lysosome-like buffer were much higher as a result of the influence of MB diffusion on the destruction of drug carrier.

Key words: sustained-release behavior, octacalcium phosphate, degradation, silica, methylene blue

CLC Number: 

  • TQ174
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