JOURNAL OF SHANDONG UNIVERSITY (ENGINEERING SCIENCE) ›› 2016, Vol. 46 ›› Issue (3): 99-105.doi: 10.6040/j.issn.1672-3961.0.2016.115

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The influence of SDS on C-343 solubilizing behavior in SB-16 micelle

BAI Yanyan1, CAO Yuexin2, ZHANG Xianxi1, ZHANG Luge1, SUN Dezhi1, YAN Hui1, ZHANG Chong1*   

  1. 1. School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, Shandong, China;
    2. Pharmacy Department, Shandong Medical College, Jinan 250002, Shandong, China
  • Received:2016-04-07 Online:2016-06-30 Published:2016-04-07

Abstract: In order to explore the dissolutive law of coumarin(C-343)in the SDS(sodium dodecyl sulfate)/SB-16(N-hexadecyl-N,N-dimethylammonio-1-propanesulfonate)synergistic system, the solvation of C-343 in pure SB-16 micelle solution and the additive of SDS surfactant influencing this solvation process were performed based on molecular dynamics method. The results showed that the C-343 could be spontaneously dissolved in the pure SB-16 micelle in equilibrium at 298 K and 101.3 kPa. After addition of SDS, the SB-16 micelle appeared slightly swollen and its outer surface was inserted by the hydrophobic tails of SDS, forming a thinner SDS outshell covering the SB-16 micelle. Simultaneously, migration of C-343 from the inner of SB-16 micelle back to the outsurface of SDS shell took place due to the hydrohobic and electrostatic interactions. This work provided one convincing evidence that adding certain surfactants in some kinds of micelles could effectively control the solubilization or release behaviors of some drugs in these solutions, and thus give one helpful guidance for those corresponding experimental studies accordingly.

Key words: coumarin(C-343), sodium dodecyl sulfate(SDS), molecular dynamics simulation, N-hexadecyl-N,N-dimethylammonio-1-propanesulfonate(SB-16), solubilization, drug release

CLC Number: 

  • X13
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