模拟体液法制备仿生纳米级羟基磷灰石

山东大学学报(工学版)

模拟体液法制备仿生纳米级羟基磷灰石

张爱娟

山东理工大学材料科学与工程学院, 山东淄博 255049

收稿日期:2008-01-17 修回日期:1900-01-01 出版日期:2008-10-16 发布日期:2008-10-16
通讯作者: 张爱娟

Preparation of biomimetic nanograde hydroxyapatite in simulated body fluid

ZHANG Ai-juan

School of Material Science and Engineering, Shandong University of Technology, Zibo 255049， China

Received:2008-01-17 Revised:1900-01-01 Online:2008-10-16 Published:2008-10-16
Contact: ZHANG Ai-juan

摘要/Abstract

摘要： 以模拟体液为溶剂,磷酸钠和硝酸钙为溶质反应合成了纳米羟基磷灰石(HAP)粉体.利用X射线衍射、红外吸收光谱、扫描电子显微镜、X光电子能谱、原子吸收分光光度计对合成的HAP粉体的物相组成、化学组成、微观形貌、及体外生物活性进行了研究.用化学方法分析了羟基磷灰石晶体的Ca／P摩尔比.结果表明:合成的HAP晶体呈针状,长约60～70nm,宽约10～20nm,具有弱结晶结构,含有Na⁺、CO₂^-3基团,更接近于自然骨磷灰石的结构特点.HAP具有一定诱导钙、磷沉积的能力.

关键词: 模拟体液, 纳米羟基磷灰石, 仿生合成, Ca／P摩尔比

Abstract: Nanograde hydroxyapatite(HAP)powders were synthesized through the reaction between Ca(NO₃)₂ and Na₃PO₄ in simulated body fluid(SBF). The mass phase composition, chemical composition, micromorphology and the bioactivity of the obtained HAP were studied by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscope, X-ray photoelectron spectroscopy, and atomic absorption spectrometry. The Ca／P molar ratio of HAP was obtained by a chemical method. The results indicate that the synthesized HAP is a pinlike shape close to natural bone with 60～70?nm length, 10～20nm width, poor crystal structure and contains Na+ and CO₂^-3. The synthesized HAP powders have a good ability for inducing Ca and P deposition.

Key words: simulated body fluid, nano-hydroxyapatite, biomimetic method, Ca／P molar ratio

中图分类号:

TQ174

张爱娟 . 模拟体液法制备仿生纳米级羟基磷灰石[J]. 山东大学学报(工学版), 2008, 38(5): 102-106 .

ZHANG Ai-juan . Preparation of biomimetic nanograde hydroxyapatite in simulated body fluid[J]. JOURNAL OF SHANDONG UNIVERSITY (ENGINEERING SCIENCE), 2008, 38(5): 102-106 .

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[2]	张爱娟. 模拟体液中类骨羟基磷灰石的合成[J]. 山东大学学报(工学版), 2010, 40(3): 86-90.