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山东大学学报(工学版) ›› 2016, Vol. 46 ›› Issue (3): 106-111.doi: 10.6040/j.issn.1672-3961.0.2015.395

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亚甲基蓝自二氧化硅@磷酸八钙载药颗粒的释放行为

李成峰,刘群,王文浩,王百威,杨赞中   

  1. 山东理工大学材料科学与工程学院, 山东 淄博 255049
  • 收稿日期:2015-12-02 出版日期:2016-06-30 发布日期:2015-12-02
  • 作者简介:李成峰(1979— ),男,山东青州人,副教授,博士,主要研究方向为生物医用材料. E-mail: cfli@sdut.edu.cn
  • 基金资助:
    山东省自然科学基金资助项目(ZR2013EML008,ZR2012EMM016);山东省高等学校科技计划资助项目(J11LD52);山东省科技发展计划资助项目(2014GZX201008)

Investigation of the release behavior of methylene blue from silica@octacalcium phosphate as drug carrier

LI Chengfeng, LIU Qun, WANG Wenhao, WANG Baiwei, YANG Zanzhong   

  1. School of Materials Science and Engineering, Shandong University of Technology, Zibo 255049, Shandong, China
  • Received:2015-12-02 Online:2016-06-30 Published:2015-12-02

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摘要： 采用改性的Pechini方法在含亚甲基蓝(methylene blue, MB)的二氧化硅颗粒(silica-MB)表面沉积磷酸八钙(octacalcium phosphate, OCP)后制备得到silica-MB@OCP,研究制备工艺条件对载药颗粒的结构、药物释放行为和载体降解性能的影响规律。研究发现聚乙二醇(polyethylene glycol, PEG)的分子量、PEG和柠檬酸的添加量对载药颗粒的物相、化学组成和形貌有显著影响。MB释放量和单体/二聚体的比例随时间的变化规律都对载药颗粒的结构和溶液pH值条件敏感,这与MB分子扩散行为受OCP壳层的结构和溶液条件影响有关。相比于silica-MB, silica-MB@OCP在磷缓冲液和lysosome-like缓冲液中的降解比例要高得多,这是由于MB扩散行为对颗粒结构的破坏产生显著影响导致的。

关键词: 药物缓释, 磷酸八钙, 亚甲基蓝, 二氧化硅, 降解

Abstract: A modified Pechinni method was employed to synthesize the drug carrier of silica-MB@OCP, which was achieved through deposition of octacalcium phosphate(OCP)on MB-loaded silica particle(silica-MB). The influences of reaction conditions on structural evolution of drug carrier, modulation of release behaviors and decomposition of drug vehicle were studied. The phase, chemical constitution and morphology of silica-MB@OCP were significantly influenced by the molecular weight of polyethylene glycol(PEG), adding amount of PEG and citric acid. The variations of the cumulative release and the ratio of monomer versus dimers of MB with time were sensitivity with the structure of silica-MB@OCP and the pH value of culture solution, which influenced the diffusion of MB. In comparison with those of silica-MB, the degradation ratios of silica-MB in phosphate buffered saline and lysosome-like buffer were much higher as a result of the influence of MB diffusion on the destruction of drug carrier.

Key words: sustained-release behavior, octacalcium phosphate, degradation, silica, methylene blue

中图分类号: 

  • TQ174
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