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山东大学学报(工学版) ›› 2010, Vol. 40 ›› Issue (4): 47-52.

• 控制科学与工程 • 上一篇    下一篇

蒙特卡罗方法模拟生物组织中光的分布

高迪,魏守水*,任晓楠,崔建强,徐从娟   

  1. 山东大学控制科学与工程学院, 山东 济南 250061
  • 收稿日期:2009-09-14 出版日期:2010-08-16 发布日期:2009-09-14
  • 通讯作者: 魏守水(1965-),男,山东淄博人,教授,博士生导师,主要研究方向为微机控制技术、生物医学信号处理、生物微机电系统. E-mail:E-mail:sswei@sdu.edu.cn
  • 作者简介:高迪(1984-),男,山东淄博人,硕士研究生,主要研究方向为生物组织建模与仿真.E-mail: gaodidme@mail.sdu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目(10572078);山东省自然科学基金资助项目(Y2007A16)

Simulation for the light distribution in bio-tissues by the Monte Carlo method

GAO Di, WEI Shou-shui*,  REN Xiao-nan, CUI Jian-qiang, XU Cong-juan   

  1. School of Control Science and Engineering, Shandong University, Jinan 250061, China
  • Received:2009-09-14 Online:2010-08-16 Published:2009-09-14

摘要:

用蒙特卡罗方法模拟了准直激光束垂直入射于生物组织的过程,分析了光子在生物组织中的运动轨迹、光学参数对能量分布的影响、吸收能量密度和光能流率随组织厚度和半径的变化情况、组织表面径向和角向分辨的漫反射率的变化情况,并利用卷积模拟了高斯光束与平圆光束在生物组织中的传输。结果表明: 准直光束入射组织时,能量主要集中在中央束轴附近;g因子增大,光子前向运动增强;吸收系数μa增大,光子数的分布沿纵向和径向会同时减小;光能流率与吸收能量密度相比变化平滑;高斯光束的能量分布比平圆光束集中,变化迅速,中心位置处吸收能量密度大。

关键词: 蒙特卡罗方法, 生物组织, 吸收能量密度, 漫反射

Abstract:

 A Monte Carlo method was used to study the light distribution in biotissues with a collimated light beam. The track of photons propagation, the energy intensity distribution with optical parameters, the absorption energy density and internal fluence with depths and radius, the change of radially and angularly resolved diffuse reflectances were analyzed. The propagation of the Gaussian beam and circularly flat beam in biotissues was simulated by using convolution. The results showed that when a collimated light beam propagated in the tissue, the energy was mainly concentrated in the vicinity of the central axis. The photons forward movement was enhanced when the g factor was increased. When the absorption coefficient became larger, the distribution of photons was reduced along the vertical and horizontal axis. The internal fluence changed more smoothly than the absorption energy density. The energy distribution of the Gaussian beam had a larger concentration than that of a circularly flat beam, changed more rapidly and had a larger energy absorption in the center.

Key words:  Monte Carlo method, bio-tissue, absorption energy density, diffuse reflectance

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