有机泡沫浸渍法制备多孔羟基磷灰石生物支架的研究

山东大学学报(工学版) ›› 2012, Vol. 42 ›› Issue (3): 105-109.

有机泡沫浸渍法制备多孔羟基磷灰石生物支架的研究

张爱娟,高增丽,王卫伟,李成峰

山东理工大学材料科学与工程学院, 山东淄博 255049

收稿日期:2011-05-17 出版日期:2012-06-20 发布日期:2011-05-17
作者简介:张爱娟(1976- ),女,山西襄汾人,讲师,主要研究方向为生物医用材料的制备与性能评价.E-mail: zhangaijuan@sdut.edu.cn
基金资助:
山东省高等学校科技计划资助项目(J11LD52)

Study of the porous hydroxyapatite scaffold prepared by dipping with polymer foams

ZHANG Ai-juan, GAO Zeng-li, WANG Wei-wei, LI Cheng-feng

School of Material Science and Engineering, Shandong University of Technology, Zibo 255049, China

Received:2011-05-17 Online:2012-06-20 Published:2011-05-17

摘要/Abstract

摘要：

以聚氨酯海绵为模板,采用浸渍法合成了孔隙率可控的羟基磷灰石(hydroxyapatite, HAP)生物支架。首先自制了羟基磷灰石粉体, 并借助X射线衍射对其进行了物相组成的分析;其次,利用聚氨酯海绵自身均匀的孔隙结构,采用浸渍法制备了多孔羟基磷灰石支架。支架孔隙率的高低与浸渍次数有关, 可达45％～90％。支架的扫描电子显微镜(SEM)分析显示,多孔支架孔形状近似为圆形,尺寸400μm左右。随浸渍次数的增加,支架的抗压强度会相应增高,浸渍5次可达3。51MPa,满足临床要求。最后还对支架的生物亲和性进行了研究,结果表明制备的羟基磷灰石支架在人体环境中具有一定的生物亲和性。

关键词: 多孔羟基磷灰石, 聚氨酯, 浸渍, 孔隙率, 生物亲和性, 抗压强度

Abstract:

Using a polyurethane sponge as a template, hydroxyapatite scaffolds with adjustable porosity were synthesized by the dipping method. First, the HAP powders were prepared and their phase composition were also analyzed. Second, the porous hydroxyapatite scaffolds were made by dipping polyurethane sponge with a uniform pore structure into slurry, and the dipping times could change the porosity of scaffolds from 45％ to 90％.The pores of porous scaffolds were round in shape and 400μm in diameter. With the dipping times increasing, the compressive strength of porous scaffolds correspondingly heightened and reached 3..51MPa after 5 times of dipping, which could meet the clinical requirements. Finally, the biological compatibility of scaffolds was also studied and a conclusion was obtained that the hydroxyapatite scaffolds had certain biological affinity in human environments.

Key words: biological compatibility, compressive strength, porous hydroxyapatite, polyurethane, dipping, porosity

张爱娟,高增丽,王卫伟,李成峰. 有机泡沫浸渍法制备多孔羟基磷灰石生物支架的研究[J]. 山东大学学报(工学版), 2012, 42(3): 105-109.

ZHANG Ai-juan, GAO Zeng-li, WANG Wei-wei, LI Cheng-feng. Study of the porous hydroxyapatite scaffold prepared by dipping with polymer foams[J]. JOURNAL OF SHANDONG UNIVERSITY (ENGINEERING SCIENCE), 2012, 42(3): 105-109.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	卜良桃,袁海涛. 纤维水泥砂浆与混凝土粘结性能双面剪切试验研究[J]. 山东大学学报(工学版), 2016, 46(4): 76-82.
[2]	周海龙,申向东,薛慧君. 小龄期水泥土无侧限抗压强度试验研究[J]. 山东大学学报(工学版), 2014, 44(1): 75-79.
[3]	葛智1,王昊2*,郑丽1,毛洪录1. 废黏土砖粉混凝土的性能研究[J]. 山东大学学报(工学版), 2012, 42(1): 104-105.
[4]	葛智1,王昊2,张堃1,李鹏承1. 塑料砂浆的性能研究[J]. 山东大学学报(工学版), 2012, 42(1): 106-108.
[5]	刘辉晖,范同祥*. 蝶翅结构多孔二氧化钛的制备与光催化性能研究[J]. 山东大学学报(工学版), 2011, 41(1): 58-61.
[6]	郭德栋1,2,许宏妹3,李小刚4. 多孔安山岩在沥青路面中的应用研究[J]. 山东大学学报(工学版), 2010, 40(3): 133-136.