关键词: 时间间隔, 视觉诱发电位, 神经不应期, 感觉门控, 前脉冲抑制

Abstract: Influence of interstimulus interval (ISI) of two stimuli on visual evoked potential (VEP) of human was investigated in this research, when the human subjects were presented with a pair of flashes as stimuli. It was indicated that preceding visual stimulus inhibited the amplitude of the evoked potential of the succeeding visual stimulus. The inhibition was dependent on ISI of the two stimuli, and the shorter the ISI the stronger the inhibition would be. The evoked potential of the succeeding stimulus was inhibited completely by the preceding stimulus when the ISI was shorter than 250?ms. VEP of the succeeding stimulus emerges gradually and the amplitude of the VEP becomes larger with the ISI longer and longer than 250?ms. The prepulse inhibition reflects the neural refractory effect of brain in response to continuous stimuli. Prepulse inhibition phenomena suggest that the principle of time priority encoding and principle of time weighting encoding is followed in brain information processing. The research will be applied in brain function, in pathology and diagnosis of schizophrenia.

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