超滤膜分离提纯苦楝素

山东大学学报(工学版) ›› 2011, Vol. 41 ›› Issue (3): 154-159.

超滤膜分离提纯苦楝素

王龙德1, 崔鹏2, 路绪旺2, 佟玲1, 姚路路2

1. 淮南师范学院化学与化工系, 安徽淮南 232001;
2. 安徽省可控化学与材料化工重点实验室(合肥工业大学), 安徽合肥 230009

收稿日期:2010-10-25 出版日期:2011-06-16 发布日期:2010-10-25
作者简介:王龙德(1972- ),男,山东日照人,讲师,硕士,主要研究方向为材料合成及传质与分离.Email:ldwang72@126.com
基金资助:
安徽省高等学校省级自然科学基金资助项目(KJ2009B264Z)

Separation and purification of toosendanin extraction solution
by an ultrafiltration membrane

WANG Longde1, CUI Peng2, LU Xuwang2, TONG Ling1, YAO Lulu2

1. Department of Chemistry and Chemical Engineering, Huainan Normal College, Huainan 232001, China;
2.The Key laboratory of Controllable Chemical Reaction ＆ Material Chemical Engineering of Anhui Province,
Hefei University of Technology, Hefei 230009, China

Received:2010-10-25 Online:2011-06-16 Published:2010-10-25

摘要/Abstract

摘要：

研究了微孔滤膜和超滤膜从苦楝树皮的微波提取液中膜分离提纯苦楝素的相关膜工艺条件及参数,并筛选出较为理想的聚砜超滤膜。研究结果表明,截留分子量为6K的聚砜UEOS-503超滤膜分离提纯苦楝素的效果要优于截留分子量分别为10K和20～50K的聚砜USIC-503 和 UPIS-503。为提高苦楝素的纯度和苦楝素转移率,得出超滤膜分离提纯苦楝素优化工艺条件:料液质量浓度为0.369mg／mL,料液温度35℃,膜操作压力差为0.10MPa,膜面流速6.17×10^-4m／s,膜滤液pH=7.0。在优化条件下,苦楝素的转移率为92.8％,提取液中苦楝素的纯度由0.89％,提高到15.22％。

关键词: 苦楝, 苦楝素, 超滤膜, 提纯

Abstract:

Microfiltration and ultrafiltration membrane separation methods were studied for purifying toosendanin from crude extracts of the bark of azedarach by microwave-assisted extraction. The polysulfone ultrafiltration membranes UEOS-503, USIC-503 and UPIS-503 were studied for separating and purifying toosendanin. The results showed that polysulfone UEOS-503 ultrafiltrating membrane with retenting molecular weight 6 K was much better than USIC-503(10K) and UPIS-503(20～50K) in separating and purifying toosendanin. In order to improve the toosendanin purity and transfer rate, the optimal separating and purifying conditions were investigated and obtained as follows: the raw concentration of toosendanin was 0.369mg／mL, the temperature was 35℃, the operating pressure of 0.10MPa, the cross flow velocity was 6.17×10^-4m／s, and the pH value was 7.0. Under the optimum conditions, the toosendanin transfer rate was 92.8％, and the purity of toosendanin increased from 0.89％ to 15.22％.

Key words: melia azedarach Linn, toosendanin, ultrafiltration membrane, purification

王龙德1, 崔鹏2, 路绪旺2, 佟玲1, 姚路路2. 超滤膜分离提纯苦楝素[J]. 山东大学学报(工学版), 2011, 41(3): 154-159.

WANG Longde1, CUI Peng2, LU Xuwang2, TONG Ling1, YAO Lulu2. Separation and purification of toosendanin extraction solution
by an ultrafiltration membrane[J]. JOURNAL OF SHANDONG UNIVERSITY (ENGINEERING SCIENCE), 2011, 41(3): 154-159.

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