C／C+HA骨植入材料对杂交波尔山羊生理生化机能的影响

山东大学学报(工学版)

C／C+HA骨植入材料对杂交波尔山羊生理生化机能的影响

薛成骞¹, 董建文², 孟宪锋³, 常虹⁴, 曹宁¹, 陈华英¹, 李木森¹

1. 山东大学材料科学与工程学院, 山东济南 250061;2. 山东中医药大学第二附属医院骨科, 山东济南 250001;3. 山东省农业科学院畜牧兽医研究所, 山东济南 250100;4. 济宁医学院附属医院检验科, 山东济宁 272000

收稿日期:2007-09-19 修回日期:1900-01-01 出版日期:2008-06-16 发布日期:2008-06-16
通讯作者: 薛成骞

The effect of C／C+HA bonerepairing material to the physiological and biochemical response of the crossed Boer Goat

XUE Cheng-qian¹, DONG Jian-wen², MENG Xian-feng³, CHANG Hong⁴,CAO Ning¹, CHEN Hua-ying1, LI Mu-sen¹

1. School of Materials Science and Engineering, Shandong University, Jinan 250061, China;2. Department of Orthopedics, Second Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China;3. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Science, Jinan 250100, China;4. Department of Inspection, Hospital of Jining Medicine College, Jining 272000, China

Received:2007-09-19 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
Contact: XUE Cheng-qian

摘要/Abstract

摘要： 碳／碳复合材料+羟基磷灰石涂层(C／C+HA)骨植入材料具有与人体骨组织十分接近的弹性模量和优良的表面生物活性,是一种具有重要临床应用价值的骨替换材料.采用杂交波尔山羊作为动物实验模型,开展了C／C+HA复合材料骨内植入实验,并从呼吸、心跳、消化、血液和免疫等方面考察了该植入材料对实验动物生理、生化指标的影响,进而探讨了该材料的生物安全性.结果表明:在植入手术后61?d的观察期内,虽然实验动物出现轻度贫血和消化吸收功能下降,但未发现C／C+HA复合材料引起的热源性反应、急性感染和免疫功能下降,说明该材料具有较好的生物安全性.

关键词: C／C+HA复合材料, 山羊, 生理指标, 生化指标

Abstract: Carbon／carbon composite material with hydroxyapatite coating (C／C+HA) bone-implant materials has elastic modulus, which is highly close to human bone tissue and of excellent surface biological activity, and has great value of clinical application as a kind of bone replacement material. This study adopted the crossed Boer Goat as the animal experimental model, developed the experiment of C／C+HA composites implanted into bone, and investigated the effect of this implant material on the physiological and biochemical index of the test animal in breathing, heartbeat, digestion, blood and immunity, etc. The results show that although the test animals appeared mildly anemia and their digestion and absorption declined, heat source reaction, acute infection and immunity function decrease were not observed during the 61-day observation period after the implant surgery. It indicates that this material has preferable biological safety.

Key words: Carbon／Carbon+hydroxyapatite composite materials, goat, physiological index, biochemical index

中图分类号:

TB332

薛成骞,董建文,孟宪锋,常虹,曹宁,陈华英,李木森 . C／C+HA骨植入材料对杂交波尔山羊生理生化机能的影响[J]. 山东大学学报(工学版), 2008, 38(3): 73-76 .

XUE Cheng-qian,DONG Jian-wen,MENG Xian-feng,CHANG Hong,CAO Ning,CHEN Hua-ying,LI Mu-sen . The effect of C／C+HA bonerepairing material to the physiological and biochemical response of the crossed Boer Goat[J]. JOURNAL OF SHANDONG UNIVERSITY (ENGINEERING SCIENCE), 2008, 38(3): 73-76 .

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