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Study on associations between serum per- and polyfluoroalkyl substances levels and blood pressure in residents of Jinan
ZHANG Haoyu, XU Fei, LIU Yi, HOU Chengxi, DING Lei
Journal of Shandong University(Engineering Science)
2025, 55 (4):
160-172.
DOI: 10.6040/j.issn.1672-3961.0.2024.297
Human was exposed to per- and polyfluoroalkyl substances(PFASs), which were implicated to be associated with elevated prevalence of hypertension. To evaluate the relationships between individual PFAS and PFAS mixture with blood pressure levels and hypertension risk, 18 PFASs in fasting serum samples collected from 326 individuals in Jinan, China were analyzed with an ultrahigh performance liquid chromatography system coupled with an Orbitrap mass spectrometer. Multivariable linear regression and logistic regression models were utilized to analyze the associations between individual PFAS and systolic blood pressure, diastolic blood pressure, and the risk of hypertension, respectively. To evaluate the joint effects of PFAS mixture, quantile g-computation and Bayesian kernel machine regression models were applied. All the models indicated a positive association between perfluorodecanoic acid mass concentration and diastolic blood pressure, a negative association between perfluorododecanoic acid mass concentration and diastolic blood pressure, and a positive association between perfluoroundecanoic acid mass concentration and risk of hypertension. According to a series of results from this study, it was concluded that both diastolic blood pressure and the risk of hypertension increased with the percentile of PFAS mixture mass concentration among the study population.
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