山东大学学报 (工学版)    2021 51 (2): 26-33   ISSN: 1672-3961  CN: 37-1391/T  

LncRNA与疾病关系的知识图谱构建
龚乐君1,2,杨璐1,高志宏3,李华康1,4,5
1.南京邮电大学计算机学院、软件学院、网络空间安全学院, 江苏 南京 210023;2.江苏省大数据安全与智能处理重点实验室, 江苏 南京 210023;3.浙江省智慧医疗工程技术研究中心, 浙江 温州 325035;4.自然资源部城市国土资源监测与仿真重点实验室, 广东 深圳 518034;5.苏州派维斯信息科技有限公司, 江苏 苏州 215011
收稿日期 null  修回日期 null  网络版发布日期 2021-04-16
参考文献  [1] CLACK M B, MATTICK J S. Long noncoding RNAs in cell biology[J]. Seminars in Cell & Developmental Biology, 2011, 22(4):366-376.
[2] LOURO R, SMIRNOVA A S, VERNOVSKI-ALMEIDA S. Long intronic noncoding RNA transcription: expression noise or expression choice?[J]. Genomics, 2009, 93(4):291-298.
[3] GEISLER S, COLLER J. RNA in unepected places:long non-coding RNA functions in diverse cellular contexts[J]. Nature Reviews Molecular Cell Biology, 2013, 14(11):699-712.
[4] CHEN X, YAN C C, LUO C, et al. Constructing lncRNA functional similarity netword based on lncRNA-disease associations and disease semantic similarity[J]. Scientific Reports, 2015, 5:11338.
[5] SUN J, SHI H B, WANG Z Z, et al. Inferring novel lncRNA-disease associations based on a random walk model of a lncRNA functional similarity network[J]. Molecular Biosystems, 2014, 10(8):2074-2081.
[6] 周众. LncRNA-基因调控关系的生物信息学数据库构建及分析预测[D].合肥:中国科学技术大学,2016. ZHOU Zhong. Bioinformatics database construction, analysis and prediction of LncRNA-gene regulatory relation-ships[D]. Hefei:University of Science and Technology of China, 2016.
[7] 朱木易洁,鲍秉坤,徐常胜. 知识图谱发展与构建的研究进展[J]. 南京信息工程大学学报(自然科学版),2017,9(6):575-582. ZHU Muyijie, BAO Bingkun, XU Changsheng. Research progress on development and construction of knowledge graph[J]. J Nanjing Univ Inf Sci Technol, 2017, 9(6):575-582.
[8] LIU Q, LI Y, DUAN H, et al. Knowledge graph construction techniques[J]. Journal of Computer Research and Development, 2016, 53(3): 582-600.
[9] MENG X F, DU Z J. Research on the big data fusion: issues and challenges[J]. Journal of Computer Research and Development, 2016, 53(2):231-246.
[10] DUAN Y, SHAO L, HU G. Specifying knowledge graph with data graph, information graph, knowledge graph, and wisdom graph[J]. International Journal of Software Innovation, 2018, 6(2):10-25.
[11] ZELENKO D, AONE C, RICHARDELLA A. Kernel methods for relation extraction[J]. Journal of Machine Learning Research, 2003, 3:1083-1106.
[12] WANG J,WANG Z, ZHANG D, et al. Combining knowledge with deep convolutional neual Nnetworks for short text classification[C] //Proc of the Twenty-Sixth International Joint Conference on Artifical Intelligence. Melbourne, Australia: Sierra C, 2017:2915-2921.
[13] LIU M X, CHEN X, CHEN G, et al. A computational framework to infer human disease-ass-ociated long noncoding RNAs[J]. PLoS One, 2014, 9(1):e84408.
[14] CHEN X. Predicting lncRNA-disease associateions and constructing lncRNA functional similarity network based on the information of miRNA[J]. Scientific Reports, 2015, 5:13186.
[15] MORRAN V A, PERERA R J, KHALIL A M. Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs[J]. Nucleic Acids Res, 2012, 40(14):6391-6400.
[16] WISHART D S, KNOX C, SHRIVASTAVA S, et al. A knowledgebase for drugs, drug actions and drug targets[J]. Nucleic Acids Res, 2008, 36(Database issue):D901-6.
[17] VOLDERS P J, HELSENS K, WANG X, et al. LNCipedia: a database for annotated human lncRNA tran-script sequences and structures[J]. Nucleic Acids Research, 2013, 41(Database issue):D246-D251.
[18] LYNN S, ARZE C, NADENDLA S, et al. Disease ontology: a backbone for disease semantic integration[J]. Nucleic Acids Res, 2012, 40(Database issue):D940-D946.
[19] CHEN G, WANG Z, WANG D, et al. LncRNA disease: a database for long-noncoding RNA-associated diseases[J]. Nucleic Acids Res, 2013, 41(D1):D983-986.
[20] BAO Z, YANG Z, HUANG Z, et al. LncRNA Disease 2.0: an updated database of long non-coding RNA-associated diseases[J]. Nucleic Acids Res, 2019, 47(D1):D1034-D1037.
[21] 杨霄月, 李建伟. LncRNA调控人类疾病关系数据库的研究[J]. 医学信息, 2019, 32(12):28-30. YANG Xiaoyue, LI Jianwei. LncRNA regulation of human disease relationship database[J]. Medical Information, 2019, 32(12):28-30.
[22] OLDAKOWSKI R. D2RQ platform-treating non-RDF databases as virtual RDF graphs[J/OL]. Nat Prec, 2011. https://doi.org/10.1038/npre.2011.5660.1

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