山东大学学报 (工学版) ›› 2022, Vol. 52 ›› Issue (3): 127-133.doi: 10.6040/j.issn.1672-3961.0.2021.601
• • 上一篇
张博雯,宋健,章涵穹,姜威*
ZHANG Bowen, SONG Jian, ZHANG Hanqiong, JIANG Wei*
摘要： 为探究细胞膜中不同脂质成分对γ-Fe2O3纳米颗粒物(nanoparticles,NPs)与膜相互作用的影响,参考真实细胞膜的脂质类型合成13种脂质成分不同的模型细胞膜,并测定γ-Fe2O3 NPs诱导的模型细胞膜完整性及膜流动性变化。结果表明,γ-Fe2O3 NPs能够吸附在膜上(甚至造成膜破碎)并诱导膜流动的增加。NPs与不同的模型细胞膜相互作用的强度不同,特别是鞘磷脂和胆固醇在膜中的共存(模拟脂筏的存在)会减弱NPs与膜的相互作用,而膜中正电位点的存在增强了NPs与膜的相互作用。脂质成分的不同会造成模型细胞膜表面电荷、活性基团和脂质分子堆积强度等膜性质的差异,进而影响NPs与膜相互作用的强度。本研究为探索γ-Fe2O3 NPs与细胞膜的相互作用提供了新的思路。
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